Discussions

Ask a Question
Back to all

How does Creative Biolabs address the challenge of predicting highly flexible regions like the CDR3 loop?

For more: AI-Driven Epitope Prediction

The CDR3 region is often highly variable and difficult to model (e.g., "kinked" structures). Creative Biolabs overcomes this by combining optimized AI models (leveraging technologies like AlphaFold3) with robust wet lab validation to empirically confirm predictions, ensuring high confidence even for complex targets.

Workflow & Project Management
Q4: What starting materials are required to utilize this service?
A4: To begin a project, clients typically need to provide:

Antigen Sequence or Structure.

Antibody Sequence.

Existing Binding Data (Optional, but helpful for refining the model).